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The issue of off-label indications is a problem across medications, but I think it s particularly of concern with drugs that affect mental-health issues, said Dr. David Atkins, chief medical officer at AHRQ s Center for Outcomes and Evidence. bad credit credit creditres

The revelation, contained in an AHRQ report titled Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics, was not startling to clinicians. The surprise is that people have not been more adamant about this earlier, said Dr. Julio Licinio, chairman of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine. The report comes on the heels of another study that found that antipsychotic drugs, commonly prescribed to treat psychosis, agitation and aggression in Alzheimer s patients, are essentially no more effective than a sugar pill. bad consolidation credit debt

Atypical antipsychotics such as aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal) and ziprasidone (Geodon) are designed to cause fewer neurological complications than older antipsychotics. They are approved to treat schizophrenia and bipolar disorder but are increasingly used to treat dementia, geriatric aggression, depression, obsessive-compulsive disorder, post-traumatic stress disorder and personality disorders. bad company credit repair

Using the drugs off label for conditions other than their original approval is perfectly legal but causes concern among some experts. A 2001 report by the AHRQ concluded that about 21 percent of prescribed drug use was for conditions not indicated on the label. bad card credit credit

Atypical antipsychotics have also been studied for treating Tourette syndrome and autism in children. Off-label use isn t necessarily bad, Atkins said. To say it s not an approved indication doesn t mean there s no evidence. But after reviewing 84 published studies on atypical antipsychotics, the authors of the new study concluded there can be problems. Not only is quality evidence lacking to support off-label use of the drugs, there is evidence of severe side effects, including weight gain, tremors and stroke. bad car credit loan

These drugs have a lot of side effects, Licinio confirmed. They also tend to be very expensive. Although some patients can benefit from the off-label use, many can be treated with a different drug without the side effects, he added. The drugs are also used widely in children for off-label purposes, said Dr. Cheryl Corcoran, assistant professor of psychiatry at Columbia University and a researcher in schizophrenia at the New York State Psychiatric Institute in New York City. bad credit loan mortgage

There are very few clinical trials in children, but there s enough information from other sources to show that these medications can be very problematic for children, with side effects such as weight gain, insulin resistance and changes in cholesterol, she said. auto bad credit loan

Licinio added there are few studies that looked at the drugs in real-world settings, which often means in combination with other drugs. It s not only that people are getting anti-psychotics, they are being added to what they are already taking, he said. They are being added, and they have not been tested in combinations, and I think it s a problem. bad credit mortgage refinance

The study authors called for more head-to-head trials of the drugs. The clearest finding was that the quality of evidence for the most common uses was not very clear-cut, which doesn t prove the case that these aren t appropriate to consider in individual patients. But it does say that given the amount of use they re getting, we need some better research to try to clarify how to identify the right patients to get these drugs, Atkins said. bad credit refinance

But Corcoran and others called for a different approach. Our sense is not more head-to-head trials but the need to develop other kinds of treatments for disorders other than psychosis, drugs that are safer, more appropriate, using rationale drug design, she said. More information View the full report at AHRQ. SOURCES: David Atkins, M.D., chief medical officer, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Md.; Julio Licinio, M.D., chairman, department of psychiatry and behavioral sciences, University of Miami Miller School of Medicine; Cheryl Corcoran, M.D., assistant professor of psychiatry, Columbia University, and researcher in schizophrenia, New York State Psychiatric Institute, New York City; Jan. 17, 2007, Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics, Agency for Healthcare Research and Quality bad credit mortgage second

Dental Health Articles Children s Health Health Tip Avoid Catching bad credit loan student

Keep your hands clean and free of germs Updated: 4/26/2007 3:26:47 PM Print Article Email Article (HealthDay News) -- It may seem impossible in the winter months not to catch a cold, but a few precautions may spare you the sniffles. bad card credit

To reduce your chances of catching a cold, follow these suggestions from the American Lung Association: bad credit financing

• Avoid contact with people who already have a cold, and wash your hands after being around them. bad credit home loan mortgage

• Keep your hands away from your face, especially your eyes, mouth, and nose. bad credit loan people

• Keep clean hand towels in your bathroom, and keep a separate one available for people who aren t sick. bad card credit credit people

• Keep your home humid to prevent your sinuses from drying out. bad credit guaranteed loan

Dental Health Articles Children s Health Health Tip Is Your Child bad credit refinancing

Some kids are more prone than others Updated: 4/26/2007 3:26:53 PM Print Article Email Article (HealthDay News) -- Middle ear infections are common in many children. This may be because their eustachian tubes are shorter and narrower than those of their elders, the American Academy of Family Physicians says. bad credit equity home loan

Here is the academy s list of common risk factors for child ear infections: bad credit loan payday

• Frequent exposure to secondhand smoke. bad credit repair

• Having had allergies, frequent colds, prior ear infections, or a family history of ear infections. bad credit home loan uk

• Attending day care. 2nd bad credit mortgage

• Being born prematurely or at a low birth weight. bad credit loan unsecured

• Sleeping with a bottle or using a pacifier. bad consolidation credit loan

• Being male -- boys are more likely to get ear infections than girls. bad credit home loan new

Dental Health Articles Seniors Looking for a Longer Life bad business credit loan

Study finds laureates gain almost 2 years time, not to mention the lofty social status Updated: 4/26/2007 3:26:53 PM Print Article Email Article THURSDAY, Jan. 25 (HealthDay News) -- If you want to live longer, just win a Nobel Prize. bad credit lender mortgage

Attaining that lofty award can add nearly two years to your life span, according to a study by researchers at the University of Warwick in the United Kingdom. The researchers conducted the study to explore whether social status alone can affect the well-being and life span of people. Previous research has found that social status does have a positive effect on the longevity of monkeys. However, it has been a challenge to separate the effects of status alone, because it s often intertwined with other factors such as wealth. The researchers decided that Nobel Prize winners were an ideal group for this kind of study because their social status occurs suddenly when they win the award. bad credit home loan mobile

For this study, the researchers compared 524 male Nobel Prize winners (135) and nominees (389) in physics and chemistry between 1901 and 1950. The average life span of the winners was 77.2 years, compared with 75.8 years for the nominees. bad cash credit loan

When the researchers compared winners and nominees from the same countries, they found that the longevity gap increased by an average of about two-thirds of a year. Status seems to work a kind of health-giving magic. Once we do the statistical corrections, walking across that platform in Stockholm apparently adds about two years to a scientist s life span. How status does this, we just don t know, study co-author Andrew Oswald, a professor of economics at the University of Warwick, said in a prepared statement. bad credit loan private

Dental Health Articles Seniors Top U S Hospitals Have 28% bad card credit debt

Annual survey finds growing gap between high-quality institutions and rest of the field Updated: 4/26/2007 3:26:55 PM Print Article Email Article MONDAY, Jan. 29 (HealthDay News) -- The top 5 percent of hospitals in the United States have a 28 percent lower death rate than other hospitals in the nation, a new study finds. bad business credit loan small

The analysis, released Jan. 29 by HealthGrades, an independent health care ratings company, also found that patients who have surgery at the top-rated hospitals are about five percent less likely to suffer complications than patients at other hospitals. bad bankruptcy car credit loan